:root {
  --ink: #18302b;
  --muted: #61706c;
  --line: #d8e2de;
  --soft: #f3f7f5;
  --accent: #276a5c;
  --accent-dark: #174c42;
  --accent-light: #dcece7;
  --warning: #9a621b;
  --warning-bg: #fff5df;
  --danger: #9a3434;
  --danger-bg: #fff0f0;
  --ok: #2f6b59;
  --ok-bg: #e7f3ee;
  --white: #ffffff;
  --shadow: 0 14px 34px rgba(26, 61, 53, 0.08);
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body {
  margin: 0;
  color: var(--ink);
  background: #edf3f0;
  font-family: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
}
button, input, textarea { font: inherit; }
button { cursor: pointer; }
[hidden] { display: none !important; }

.app-shell { width: min(1320px, calc(100% - 32px)); margin: 28px auto 56px; }
.hero-card, .panel {
  background: var(--white);
  border: 1px solid var(--line);
  border-radius: 16px;
  box-shadow: var(--shadow);
}
.hero-card { display: grid; grid-template-columns: minmax(0, 1.5fr) minmax(280px, .7fr); gap: 22px; padding: 24px; margin-bottom: 20px; }
.hero-card h2 { margin: 3px 0 10px; font-size: clamp(1.65rem, 3vw, 2.3rem); letter-spacing: -.035em; }
.hero-card p { margin: 0; color: var(--muted); line-height: 1.6; }
.hero-rule { align-self: stretch; border: 1px solid #c9ddd6; border-radius: 14px; background: linear-gradient(145deg, #f9fcfb, var(--accent-light)); padding: 18px; }
.hero-rule strong { display: block; color: var(--accent-dark); margin-bottom: 7px; }
.hero-rule span { color: var(--muted); line-height: 1.5; }

.workspace-grid { display: grid; grid-template-columns: 220px minmax(0, 1fr); gap: 22px; align-items: start; }
.side-nav {
  position: sticky;
  top: 102px;
  display: grid;
  gap: 6px;
  padding: 16px 12px;
  border: 1px solid var(--line);
  border-radius: 16px;
  background: rgba(255,255,255,.94);
  box-shadow: var(--shadow);
}
.side-nav-title { padding: 0 9px 8px; color: var(--accent); font-size: 12px; font-weight: 900; letter-spacing: .08em; text-transform: uppercase; }
.side-nav a { display: grid; grid-template-columns: 28px 1fr; gap: 5px; align-items: center; padding: 9px; border-radius: 10px; color: #52645f; font-size: 13px; font-weight: 750; text-decoration: none; }
.side-nav a:hover { background: var(--accent-light); color: var(--accent-dark); }
.side-nav span { color: var(--accent); font-weight: 900; }

.main-column { min-width: 0; }
.panel { padding: 24px; margin-bottom: 18px; }
.panel-heading { display: flex; align-items: flex-start; justify-content: space-between; gap: 20px; margin-bottom: 18px; }
.panel-heading-group { display: flex; align-items: center; gap: 12px; min-width: 0; }
.panel-step-badge { display: inline-flex; align-items: center; justify-content: center; min-width: 42px; height: 32px; padding: 0 10px; border-radius: 12px; background: #d8e9e4; border: 1px solid #c4ddd5; color: var(--accent-dark); font-size: .88rem; font-weight: 900; line-height: 1; }
.panel-heading h2 { margin: 2px 0 0; font-size: 1.4rem; }
.section-note { color: var(--muted); line-height: 1.55; margin: -6px 0 18px; }

.input-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 14px; }
.field { display: grid; gap: 7px; color: var(--ink); font-weight: 700; }
.field > span { font-size: .92rem; }
.field-help { color: var(--muted); font-size: .82rem; font-weight: 400; line-height: 1.45; }
input[type="number"], textarea { width: 100%; border: 1px solid #c9d5d0; border-radius: 10px; padding: 10px 11px; background: #fff; color: var(--ink); }
input:focus, textarea:focus { outline: 3px solid rgba(39,106,92,.14); border-color: var(--accent); }

.drop-zone { border: 2px dashed #b9cec6; border-radius: 14px; background: #f8fbfa; padding: 22px; text-align: center; transition: .16s ease; }
.drop-zone.dragover { border-color: var(--accent); background: var(--accent-light); }
.drop-zone input[type="file"] { display: block; width: 100%; margin: 10px auto 0; max-width: 460px; }
.drop-zone strong { color: var(--accent-dark); }
.drop-zone p { margin: 6px 0 0; color: var(--muted); font-size: .9rem; }
.or-divider { display: flex; align-items: center; gap: 12px; margin: 18px 0; color: var(--muted); font-size: .78rem; font-weight: 850; text-transform: uppercase; letter-spacing: .08em; }
.or-divider::before, .or-divider::after { content: ""; flex: 1; height: 1px; background: var(--line); }
#fasta-text { min-height: 170px; resize: vertical; font-family: ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", monospace; font-size: .86rem; line-height: 1.45; }

.option-card { border: 1px solid var(--line); background: var(--soft); border-radius: 14px; padding: 16px; }
.option-card h3 { margin: 0 0 10px; font-size: 1rem; }
.toggle-line { display: flex; align-items: flex-start; gap: 10px; cursor: pointer; }
.toggle-line input { margin-top: 4px; width: 18px; height: 18px; accent-color: var(--accent); }
.toggle-line strong { display: block; }
.toggle-line small { display: block; color: var(--muted); line-height: 1.4; margin-top: 3px; }

.form-actions { display: flex; flex-wrap: wrap; gap: 10px; justify-content: flex-end; margin-top: 18px; }
.primary-button, .secondary-button { border-radius: 10px; padding: 11px 16px; font-weight: 800; }
.primary-button { border: 1px solid var(--accent); background: var(--accent); color: #fff; }
.primary-button:hover { background: var(--accent-dark); }
.secondary-button { border: 1px solid var(--line); background: #fff; color: var(--ink); }
.secondary-button:hover { border-color: var(--accent); color: var(--accent-dark); }
.form-message { margin: 14px 0 0; padding: 12px 14px; border-radius: 10px; background: var(--danger-bg); color: var(--danger); font-weight: 700; }
.privacy-note { margin-top: 14px; padding: 12px 14px; border-radius: 12px; background: var(--ok-bg); border: 1px solid #cde4da; color: #355f52; font-size: .9rem; line-height: 1.5; }

.summary-grid { display: grid; grid-template-columns: repeat(6, minmax(0, 1fr)); gap: 12px; }
.summary-card { border: 1px solid var(--line); border-radius: 14px; background: #fff; padding: 16px; min-width: 0; }
.summary-card span { display: block; color: var(--muted); font-size: .76rem; font-weight: 800; text-transform: uppercase; letter-spacing: .04em; }
.summary-card strong { display: block; margin-top: 6px; color: var(--accent-dark); font-size: 1.7rem; line-height: 1; }
.summary-card small { display: block; margin-top: 7px; color: var(--muted); line-height: 1.35; }

.dataset-meta { display: flex; flex-wrap: wrap; gap: 8px; margin-bottom: 16px; }
.meta-chip, .status-chip { display: inline-flex; align-items: center; border-radius: 999px; padding: 6px 9px; font-size: .76rem; font-weight: 800; }
.meta-chip { background: var(--soft); border: 1px solid var(--line); color: #4f625c; }
.status-chip.ok { color: var(--ok); background: var(--ok-bg); border: 1px solid #cbe3d8; }
.status-chip.warn { color: var(--warning); background: var(--warning-bg); border: 1px solid #efd8aa; }
.status-chip.bad { color: var(--danger); background: var(--danger-bg); border: 1px solid #edc5c5; }
.status-chip.neutral { color: #586762; background: #eef3f1; border: 1px solid #d5dfdb; }

.table-wrap { overflow: auto; border: 1px solid var(--line); border-radius: 14px; }
.results-table { width: 100%; border-collapse: collapse; min-width: 1500px; background: #fff; }
.results-table th, .results-table td { padding: 10px 9px; border-bottom: 1px solid var(--line); text-align: left; vertical-align: top; }
.results-table th { position: sticky; top: 0; z-index: 2; background: #f2f7f5; color: #50625c; font-size: .72rem; text-transform: uppercase; letter-spacing: .04em; white-space: nowrap; }
.results-table td { font-size: .82rem; }
.results-table tr:last-child td { border-bottom: 0; }
.mono { font-family: ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", monospace; }
.hash-cell { max-width: 220px; word-break: break-all; font-size: .72rem !important; }
.header-cell { min-width: 220px; max-width: 320px; word-break: break-word; }
.symbol-list { white-space: normal; color: var(--muted); }

.result-actions { display: flex; flex-wrap: wrap; gap: 9px; margin-top: 16px; }
.report-preview { border: 1px solid var(--line); border-radius: 14px; background: #fbfdfc; padding: 18px; }
.report-preview h3 { margin: 0 0 8px; }
.report-preview p, .report-preview li { color: var(--muted); line-height: 1.55; }
.report-preview ul { margin-bottom: 0; }

.method-grid { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 14px; }
.method-grid article { border: 1px solid var(--line); background: #fbfdfc; border-radius: 14px; padding: 16px; }
.method-grid h3 { margin: 0 0 8px; font-size: 1rem; }
.method-grid p { margin: 0; color: var(--muted); line-height: 1.5; }
.reference-box { margin-top: 16px; border: 1px solid var(--line); border-radius: 13px; background: #fff; padding: 14px 16px; }
.reference-box summary { cursor: pointer; color: var(--accent-dark); font-weight: 850; }
.reference-box p, .reference-box li { color: var(--muted); line-height: 1.55; }
.reference-box code { color: var(--accent-dark); }

@media (max-width: 1120px) {
  .summary-grid { grid-template-columns: repeat(3, minmax(0, 1fr)); }
  .method-grid { grid-template-columns: 1fr 1fr; }
}
@media (max-width: 900px) {
  .workspace-grid { grid-template-columns: 1fr; }
  .side-nav { position: static; grid-template-columns: repeat(4, minmax(0, 1fr)); }
  .side-nav-title { grid-column: 1 / -1; }
  .hero-card { grid-template-columns: 1fr; }
}
@media (max-width: 680px) {
  .app-shell { width: min(100%, calc(100% - 22px)); margin-top: 18px; }
  .panel, .hero-card { padding: 18px; }
  .input-grid, .method-grid { grid-template-columns: 1fr; }
  .summary-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .side-nav { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .form-actions { justify-content: stretch; }
  .form-actions button { flex: 1 1 180px; }
}